tag:treefam.tenderapp.com,2013-02-16:/discussions/questions/62-pfam-vs-treefamTreeFam: Discussion 2014-04-14T07:48:16Ztag:treefam.tenderapp.com,2013-02-16:Comment/325276472014-04-11T23:08:06Z2014-04-11T23:08:06Zpfam vs treefam<div><p>why pfam families are much larger than treefam? Same family in
pfam has many more sequences than treefam. TreeFam families are
maximum of size 1000 but Pfam has families as large as hundreds of
thousands.<br>
Thanks</p></div>Fayetag:treefam.tenderapp.com,2013-02-16:Comment/325276472014-04-14T07:48:14Z2014-04-14T07:48:14Zpfam vs treefam<div><p>Hi Faye,<br>
thanks for your interest in TreeFam.<br>
Pfam and TreeFam are different databases. While TreeFam tries to
find all gene families of full length protein sequences, Pfam tries
to identify conserved regions (e.g. domains, motifs) within those
full length protein sequences.<br>
The fact that Pfam has many larger families tells us that domains
seem to be more widely conserved than full length protein
sequence.<br>
Does that make sense?</p>
<p>Cheers,<br>
Fabian</p></div>Fabian